<p data-pid="4Tyq6eRG" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">水稻是世界上最重要的粮食作物之一,也是我国的主要粮食作物。然而,水稻生长过程中会遭受多种病害的侵害,其中最严重的是<span style="font-synthesis: style; font-weight: 600;">稻瘟病</span>、<span style="font-synthesis: style; font-weight: 600;">白叶枯</span>和<span style="font-synthesis: style; font-weight: 600;">稻曲病</span>,这三种病害被称为“水稻癌症”,每年造成全球水稻产量的10%~30%损失,严重威胁国家粮食安全和农民收入。</p>
<p data-pid="grp8FmJD" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">今年6月14日,李国田教授在《自然》上发表最新研究成果,他们通过“分子剪刀”创制了新型广谱抗病基因,实现对稻瘟病、白叶枯和稻曲病三病抗性“加持”,实现粮食大幅增产。</p>
<p style="font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-stretch: inherit; line-height: 1.5; font-optical-sizing: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; margin-top: calc(2.33333em); margin-bottom: calc(1.16667em); clear: left; font-synthesis: style; background-color: rgb(255, 255, 255); font-size: 1.2em; font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; color: rgb(18, 18, 18);"><span style="font-synthesis: style;"><b>三病:造成巨高粮食损失</b></span></p>
<p data-pid="QhcV7wcA" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><span style="font-synthesis: style; font-weight: 600;">稻瘟病</span>是由一种真菌——<span style="font-synthesis: style; font-weight: 600;">稻瘟菌</span>引起的,它可以感染水稻的叶片、茎秆、穗部等各个部位,导致叶片出现灰色或黄色的斑点,茎秆变黑腐烂,穗部变黑不结实。</p>
<p data-pid="xSbKkrCs" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><span style="font-synthesis: style; font-weight: 600;">白叶枯</span>是由一种细菌——<span style="font-synthesis: style; font-weight: 600;">白叶枯菌</span>引起的,它可以通过昆虫或机械伤口侵入水稻植株,导致叶片出现白色条纹或枯萎,茎秆断裂或空心,穗部不开花或不结实。</p>
<p data-pid="WT6INsH6" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><span style="font-synthesis: style; font-weight: 600;">稻曲病</span>是由一种病毒——<span style="font-synthesis: style; font-weight: 600;">稻曲病毒</span>引起的,它可以通过昆虫或接种传播给水稻植株,导致叶片出现黄色条纹或卷曲,茎秆变细变弱,穗部变小变形。</p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<figure data-size="normal" style="margin: 1.4em 0px; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><img src="https://pic4.zhimg.com/80/v2-a57c828147472731d340cdc618913b9f_720w.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="456" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic4.zhimg.com/v2-a57c828147472731d340cdc618913b9f_r.jpg" data-actualsrc="https://pic4.zhimg.com/v2-a57c828147472731d340cdc618913b9f_b.jpg" data-original-token="v2-a57c828147472731d340cdc618913b9f" height="456" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; cursor: zoom-in; background-color: transparent; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<p data-pid="_Sfo9IRR" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">为了防治这些“水稻癌症”,科学家们进行了长期的探索和努力。传统的方法是通过育种选择具有抗病性的水稻品种,但这种方法耗时耗力,而且难以获得对多种病原菌都有抵抗力的品种。</p>
<p data-pid="ZyynBWOR" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">近年来,随着生物技术的发展,科学家们开始尝试利用基因工程或基因编辑技术来改造水稻基因组,增强其抗病性。基因工程是将<span style="font-synthesis: style; font-weight: 600;">外源基因导入水稻基因组中</span>,使其表达特定的蛋白质或酶来抵御病原菌。基因编辑是<span style="font-synthesis: style; font-weight: 600;">利用一些特殊的分子工具</span>(如CRISPR/Cas9)来切割或修复水稻基因组中特定的序列,使其发生突变或重组来改变其功能。</p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<figure data-size="normal" style="margin: 1.4em 0px; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><img src="https://pic4.zhimg.com/80/v2-7efaf31268876f5b35724718b935ea13_720w.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="740" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic4.zhimg.com/v2-7efaf31268876f5b35724718b935ea13_r.jpg" data-actualsrc="https://pic4.zhimg.com/v2-7efaf31268876f5b35724718b935ea13_b.jpg" data-original-token="v2-7efaf31268876f5b35724718b935ea13" height="740" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; cursor: zoom-in; background-color: transparent; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<p data-pid="B0YdOsYk" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">华中农业大学李国田教授团队就是利用基因编辑技术,在Nature杂志上发表了一项重要的研究成果 。</p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<p style="font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-stretch: inherit; font-size: 1.2em; line-height: 1.5; font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-optical-sizing: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; margin-top: calc(2.33333em); margin-bottom: calc(1.16667em); clear: left; font-synthesis: style; color: rgb(18, 18, 18); background-color: rgb(255, 255, 255);"><span style="font-synthesis: style;"><b>10年科研马拉松</b></span></p>
<p data-pid="1KxkeOAn" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">他们克隆到一个广谱抗病类病斑突变体基因RBL1,并通过基因编辑创制了增强作物广谱抗病性且稳产的新基因RBL1Δ12。该新基因可以同时提高水稻对稻瘟病、白叶枯和稻曲病的抗性,而且不影响水稻的生长和产量。</p>
<p data-pid="cG4jTXrU" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">这是首次通过基因编辑技术实现水稻对多种病原菌的抗性提升,也是首次在Nature杂志上发表水稻基因编辑的研究成果。</p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<figure data-size="normal" style="margin: 1.4em 0px; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><img src="https://pic3.zhimg.com/80/v2-567b8a76b3ee67f2994148a755a6c55a_720w.webp" data-caption="" data-size="normal" data-rawwidth="817" data-rawheight="485" class="origin_image zh-lightbox-thumb lazy" width="817" data-original="https://pic3.zhimg.com/v2-567b8a76b3ee67f2994148a755a6c55a_r.jpg" data-actualsrc="https://pic3.zhimg.com/v2-567b8a76b3ee67f2994148a755a6c55a_b.jpg" data-original-token="v2-567b8a76b3ee67f2994148a755a6c55a" height="485" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; cursor: zoom-in; background-color: transparent; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<p data-pid="hjz9EZjg" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">该团队的研究成果是经过十年科研“马拉松”的艰辛付出的。他们从2009年开始,对水稻的类病斑突变体进行了深入的遗传分析和功能鉴定,<span style="font-synthesis: style; font-weight: 600;">发现了一个名为RBL1的广谱抗病基因</span>,该基因可以同时抵御真菌、细菌和病毒三种不同类型的病原菌。然而,该基因也有一个缺点,<span style="font-synthesis: style; font-weight: 600;">就是会导致水稻的产量下降。</span></p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<figure data-size="normal" style="margin: 1.4em 0px; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><img src="https://pic4.zhimg.com/80/v2-0bb54d4f871c9a1a92ff9b1bba16167f_720w.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="720" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic4.zhimg.com/v2-0bb54d4f871c9a1a92ff9b1bba16167f_r.jpg" data-actualsrc="https://pic4.zhimg.com/v2-0bb54d4f871c9a1a92ff9b1bba16167f_b.jpg" data-original-token="v2-0bb54d4f871c9a1a92ff9b1bba16167f" height="720" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; cursor: zoom-in; background-color: transparent; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<p data-pid="xMRqYLqK" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">为了解决这个问题,他们利用CRISPR/Cas9这个“分子剪刀”,对RBL1基因进行了精准的编辑,切掉了其中一个编码区域,<span style="font-synthesis: style; font-weight: 600;">创造了一个新的基因RBL1Δ12</span>。他们发现,这个新基因不仅保持了原来的广谱抗病性,而且还消除了对水稻产量的负面影响。他们还将这个新基因导入其他水稻品种中,发现其效果也很好。</p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<figure data-size="normal" style="margin: 1.4em 0px; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><img src="https://pic1.zhimg.com/80/v2-ea15196118f8df2eb733cf91a8f15108_720w.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="810" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic1.zhimg.com/v2-ea15196118f8df2eb733cf91a8f15108_r.jpg" data-actualsrc="https://pic1.zhimg.com/v2-ea15196118f8df2eb733cf91a8f15108_b.jpg" data-original-token="v2-ea15196118f8df2eb733cf91a8f15108" height="810" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; cursor: zoom-in; background-color: transparent; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<p data-pid="0R9-Jok-" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">他们决定向世界科研顶尖《自然》投稿“冲刺”!但为了发表这项研究成果,他们也经历了不少挫折和困难。</p>
<p data-pid="4moWtepz" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><span style="font-synthesis: style; font-weight: 600;">“一稿既是信心的体现,也是‘试水’,能给一个修改机会就算成功!”</span>沙干和孙鹏说,那段时间很紧张,每天晚上忙到凌晨,第二天第一件事就是打开邮箱看有没有回复。</p>
<p data-pid="7jryFeHj" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">如果说第一稿是“探路”,那第二稿就是<span style="font-synthesis: style; font-weight: 600;">焦虑</span>,<span style="font-synthesis: style; font-weight: 600;">因为可能文章直接被拒</span>。幸运的是他们抓住机会补充实验<span style="font-synthesis: style; font-weight: 600;">,用98页纸耐心回答了22页纸的问题。</span></p>
<p data-pid="arGqn3IY" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">这样的坚持是在奋斗中铸造出来的。实验室的师生经常用2018年前后建立实验室的经历激励自己……那是2017年11月,李国田决定在华中农大工作,但实际上因为博后的结项工作,直到2018年9月他才到学校报道。</p>
<p data-pid="NdYbPVSa" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">让他至今回想起来还很感动的是,在来校之前,学校提前为他招收了4名硕士和2名博士!但他们面对的情况是,师生6个人必须“从零开始”,从无到有组建实验室。</p>
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<figure data-size="normal" style="margin: 1.4em 0px; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><img src="https://pic3.zhimg.com/80/v2-4ce5c316f2f859c67cadcc18c468ec22_720w.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="720" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic3.zhimg.com/v2-4ce5c316f2f859c67cadcc18c468ec22_r.jpg" data-actualsrc="https://pic3.zhimg.com/v2-4ce5c316f2f859c67cadcc18c468ec22_b.jpg" data-original-token="v2-4ce5c316f2f859c67cadcc18c468ec22" height="720" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; cursor: zoom-in; background-color: transparent; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
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<p data-pid="1E5yx-2w" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><span style="font-synthesis: style; font-weight: 600;">好在导师的精神一直激励着大家</span>。从仪器设备的购买到安装再到开展实验,整个过程不到一个月,当PCR和稻瘟病菌实现转化那一刻,师生无不欢呼!</p>
<p data-pid="jne9H7Gr" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">因为暂时没有分配到温室,<span style="font-synthesis: style; font-weight: 600;">刚回国的李国田带领同学们还在狮子山北边开垦过荒地、建设过简易温室大棚。</span></p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
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<figure data-size="normal" style="margin: 1.4em 0px;"><img src="https://pic3.zhimg.com/80/v2-81ee0069c57d4d54d7d296fd287315b6_720w.webp" data-caption="" data-size="normal" data-rawwidth="400" data-rawheight="301" class="content_image lazy" width="400" data-actualsrc="https://pic3.zhimg.com/v2-81ee0069c57d4d54d7d296fd287315b6_b.jpg" data-original-token="v2-81ee0069c57d4d54d7d296fd287315b6" height="301" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
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<p data-pid="gpS6wqDu" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">还记得那是2020年2月,杨磊同学成了团队唯一一名留校的同学。因为肩负重任,他曾鼓足勇气,径直来到空无一人的山北试验田,纵然推开大棚那一刻有剧烈的不适应,但他终究打开了试验田的那扇大门。</p>
<p data-pid="xSrgwC8A" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">事后他自豪地说:<span style="font-synthesis: style; font-weight: 600;">“我照看并保护了水稻材料!我们当时成了全国继续科学研究的少数单位之一!”</span></p>
<p data-pid="cM75WIgY" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><span style="font-synthesis: style; font-weight: 600;">有了杨磊同学照看并收获的少数几粒种子,实验得以进一步开展。没有亲身经历“苦”,就不能真切感受“甜”。</span></p>
<p data-pid="UaCD2hHu" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">2023年6月14日深夜,李国田和团队的师生坐等成果上线,这一刻是苦尽甘来的最好时光……</p>
<p data-pid="TmSYOL7w" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">他们揭示了水稻广谱抗病机制的分子基础,为进一步探索作物抗病信号转导途径提供了新的线索和方法。从应用上讲,他们创造了一种新型的广谱抗病基因,为培育高产高抗的水稻品种提供了新的材料和技术。<span style="font-synthesis: style; font-weight: 600;">该团队表示,他们将继续深入开展相关研究,并与农业部门合作,推动该技术在实际生产中的应用,为保障国家粮食安全和农民收入做出贡献。</span></p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
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<figure data-size="normal" style="margin: 1.4em 0px;"><img src="https://pic1.zhimg.com/80/v2-ebb781d2d74faa61ebf63ece7845a300_720w.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="608" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic1.zhimg.com/v2-ebb781d2d74faa61ebf63ece7845a300_r.jpg" data-actualsrc="https://pic1.zhimg.com/v2-ebb781d2d74faa61ebf63ece7845a300_b.jpg" data-original-token="v2-ebb781d2d74faa61ebf63ece7845a300" height="608" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; cursor: zoom-in; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
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<p data-pid="YHbvd_eF" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">华中农业大学李国田教授团队在攻克“水稻癌症”方面取得了重大突破,他们用“分子剪刀”创造了一种新型的广谱抗病基因,并在Nature杂志上发表了一项具有里程碑意义的研究成果。他们展示了中国科学家在生物技术领域的创新能力和国际影响力,也为我国粮食安全和农业发展提供了有力支撑。</p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
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<p data-pid="4Tyq6eRG" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><span style="font-synthesis: style; font-weight: 600; font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif;"></span><span style="font-synthesis: style; font-weight: 600; font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif;"></span></p>
<p data-pid="oXkcazK7" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">内容来源:华中农业大学官网,<a href="https://uconf.com/" class=" wrap external" target="_blank" rel="nofollow noreferrer" data-za-detail-view-id="1043" style="color: inherit; text-decoration-line: none; border-bottom: 1px solid rgb(128, 128, 128); cursor: pointer;">爱科会易</a>仅用于学术交流</p>
<p data-pid="grp8FmJD" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">今年6月14日,李国田教授在《自然》上发表最新研究成果,他们通过“分子剪刀”创制了新型广谱抗病基因,实现对稻瘟病、白叶枯和稻曲病三病抗性“加持”,实现粮食大幅增产。</p>
<p style="font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-stretch: inherit; line-height: 1.5; font-optical-sizing: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; margin-top: calc(2.33333em); margin-bottom: calc(1.16667em); clear: left; font-synthesis: style; background-color: rgb(255, 255, 255); font-size: 1.2em; font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; color: rgb(18, 18, 18);"><span style="font-synthesis: style;"><b>三病:造成巨高粮食损失</b></span></p>
<p data-pid="QhcV7wcA" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><span style="font-synthesis: style; font-weight: 600;">稻瘟病</span>是由一种真菌——<span style="font-synthesis: style; font-weight: 600;">稻瘟菌</span>引起的,它可以感染水稻的叶片、茎秆、穗部等各个部位,导致叶片出现灰色或黄色的斑点,茎秆变黑腐烂,穗部变黑不结实。</p>
<p data-pid="xSbKkrCs" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><span style="font-synthesis: style; font-weight: 600;">白叶枯</span>是由一种细菌——<span style="font-synthesis: style; font-weight: 600;">白叶枯菌</span>引起的,它可以通过昆虫或机械伤口侵入水稻植株,导致叶片出现白色条纹或枯萎,茎秆断裂或空心,穗部不开花或不结实。</p>
<p data-pid="WT6INsH6" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><span style="font-synthesis: style; font-weight: 600;">稻曲病</span>是由一种病毒——<span style="font-synthesis: style; font-weight: 600;">稻曲病毒</span>引起的,它可以通过昆虫或接种传播给水稻植株,导致叶片出现黄色条纹或卷曲,茎秆变细变弱,穗部变小变形。</p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
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<figure data-size="normal" style="margin: 1.4em 0px; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><img src="https://pic4.zhimg.com/80/v2-a57c828147472731d340cdc618913b9f_720w.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="456" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic4.zhimg.com/v2-a57c828147472731d340cdc618913b9f_r.jpg" data-actualsrc="https://pic4.zhimg.com/v2-a57c828147472731d340cdc618913b9f_b.jpg" data-original-token="v2-a57c828147472731d340cdc618913b9f" height="456" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; cursor: zoom-in; background-color: transparent; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
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<p data-pid="_Sfo9IRR" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">为了防治这些“水稻癌症”,科学家们进行了长期的探索和努力。传统的方法是通过育种选择具有抗病性的水稻品种,但这种方法耗时耗力,而且难以获得对多种病原菌都有抵抗力的品种。</p>
<p data-pid="ZyynBWOR" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">近年来,随着生物技术的发展,科学家们开始尝试利用基因工程或基因编辑技术来改造水稻基因组,增强其抗病性。基因工程是将<span style="font-synthesis: style; font-weight: 600;">外源基因导入水稻基因组中</span>,使其表达特定的蛋白质或酶来抵御病原菌。基因编辑是<span style="font-synthesis: style; font-weight: 600;">利用一些特殊的分子工具</span>(如CRISPR/Cas9)来切割或修复水稻基因组中特定的序列,使其发生突变或重组来改变其功能。</p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
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<figure data-size="normal" style="margin: 1.4em 0px; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><img src="https://pic4.zhimg.com/80/v2-7efaf31268876f5b35724718b935ea13_720w.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="740" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic4.zhimg.com/v2-7efaf31268876f5b35724718b935ea13_r.jpg" data-actualsrc="https://pic4.zhimg.com/v2-7efaf31268876f5b35724718b935ea13_b.jpg" data-original-token="v2-7efaf31268876f5b35724718b935ea13" height="740" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; cursor: zoom-in; background-color: transparent; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
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<p data-pid="B0YdOsYk" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">华中农业大学李国田教授团队就是利用基因编辑技术,在Nature杂志上发表了一项重要的研究成果 。</p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
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<p style="font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-stretch: inherit; font-size: 1.2em; line-height: 1.5; font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-optical-sizing: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; margin-top: calc(2.33333em); margin-bottom: calc(1.16667em); clear: left; font-synthesis: style; color: rgb(18, 18, 18); background-color: rgb(255, 255, 255);"><span style="font-synthesis: style;"><b>10年科研马拉松</b></span></p>
<p data-pid="1KxkeOAn" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">他们克隆到一个广谱抗病类病斑突变体基因RBL1,并通过基因编辑创制了增强作物广谱抗病性且稳产的新基因RBL1Δ12。该新基因可以同时提高水稻对稻瘟病、白叶枯和稻曲病的抗性,而且不影响水稻的生长和产量。</p>
<p data-pid="cG4jTXrU" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">这是首次通过基因编辑技术实现水稻对多种病原菌的抗性提升,也是首次在Nature杂志上发表水稻基因编辑的研究成果。</p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
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<figure data-size="normal" style="margin: 1.4em 0px; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><img src="https://pic3.zhimg.com/80/v2-567b8a76b3ee67f2994148a755a6c55a_720w.webp" data-caption="" data-size="normal" data-rawwidth="817" data-rawheight="485" class="origin_image zh-lightbox-thumb lazy" width="817" data-original="https://pic3.zhimg.com/v2-567b8a76b3ee67f2994148a755a6c55a_r.jpg" data-actualsrc="https://pic3.zhimg.com/v2-567b8a76b3ee67f2994148a755a6c55a_b.jpg" data-original-token="v2-567b8a76b3ee67f2994148a755a6c55a" height="485" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; cursor: zoom-in; background-color: transparent; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<p data-pid="hjz9EZjg" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">该团队的研究成果是经过十年科研“马拉松”的艰辛付出的。他们从2009年开始,对水稻的类病斑突变体进行了深入的遗传分析和功能鉴定,<span style="font-synthesis: style; font-weight: 600;">发现了一个名为RBL1的广谱抗病基因</span>,该基因可以同时抵御真菌、细菌和病毒三种不同类型的病原菌。然而,该基因也有一个缺点,<span style="font-synthesis: style; font-weight: 600;">就是会导致水稻的产量下降。</span></p>
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<figure data-size="normal" style="margin: 1.4em 0px; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><img src="https://pic4.zhimg.com/80/v2-0bb54d4f871c9a1a92ff9b1bba16167f_720w.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="720" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic4.zhimg.com/v2-0bb54d4f871c9a1a92ff9b1bba16167f_r.jpg" data-actualsrc="https://pic4.zhimg.com/v2-0bb54d4f871c9a1a92ff9b1bba16167f_b.jpg" data-original-token="v2-0bb54d4f871c9a1a92ff9b1bba16167f" height="720" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; cursor: zoom-in; background-color: transparent; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<p data-pid="xMRqYLqK" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">为了解决这个问题,他们利用CRISPR/Cas9这个“分子剪刀”,对RBL1基因进行了精准的编辑,切掉了其中一个编码区域,<span style="font-synthesis: style; font-weight: 600;">创造了一个新的基因RBL1Δ12</span>。他们发现,这个新基因不仅保持了原来的广谱抗病性,而且还消除了对水稻产量的负面影响。他们还将这个新基因导入其他水稻品种中,发现其效果也很好。</p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
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<figure data-size="normal" style="margin: 1.4em 0px; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><img src="https://pic1.zhimg.com/80/v2-ea15196118f8df2eb733cf91a8f15108_720w.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="810" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic1.zhimg.com/v2-ea15196118f8df2eb733cf91a8f15108_r.jpg" data-actualsrc="https://pic1.zhimg.com/v2-ea15196118f8df2eb733cf91a8f15108_b.jpg" data-original-token="v2-ea15196118f8df2eb733cf91a8f15108" height="810" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; cursor: zoom-in; background-color: transparent; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<p data-pid="0R9-Jok-" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">他们决定向世界科研顶尖《自然》投稿“冲刺”!但为了发表这项研究成果,他们也经历了不少挫折和困难。</p>
<p data-pid="4moWtepz" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><span style="font-synthesis: style; font-weight: 600;">“一稿既是信心的体现,也是‘试水’,能给一个修改机会就算成功!”</span>沙干和孙鹏说,那段时间很紧张,每天晚上忙到凌晨,第二天第一件事就是打开邮箱看有没有回复。</p>
<p data-pid="7jryFeHj" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">如果说第一稿是“探路”,那第二稿就是<span style="font-synthesis: style; font-weight: 600;">焦虑</span>,<span style="font-synthesis: style; font-weight: 600;">因为可能文章直接被拒</span>。幸运的是他们抓住机会补充实验<span style="font-synthesis: style; font-weight: 600;">,用98页纸耐心回答了22页纸的问题。</span></p>
<p data-pid="arGqn3IY" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">这样的坚持是在奋斗中铸造出来的。实验室的师生经常用2018年前后建立实验室的经历激励自己……那是2017年11月,李国田决定在华中农大工作,但实际上因为博后的结项工作,直到2018年9月他才到学校报道。</p>
<p data-pid="NdYbPVSa" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">让他至今回想起来还很感动的是,在来校之前,学校提前为他招收了4名硕士和2名博士!但他们面对的情况是,师生6个人必须“从零开始”,从无到有组建实验室。</p>
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</p>
<figure data-size="normal" style="margin: 1.4em 0px; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><img src="https://pic3.zhimg.com/80/v2-4ce5c316f2f859c67cadcc18c468ec22_720w.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="720" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic3.zhimg.com/v2-4ce5c316f2f859c67cadcc18c468ec22_r.jpg" data-actualsrc="https://pic3.zhimg.com/v2-4ce5c316f2f859c67cadcc18c468ec22_b.jpg" data-original-token="v2-4ce5c316f2f859c67cadcc18c468ec22" height="720" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; cursor: zoom-in; background-color: transparent; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<p data-pid="1E5yx-2w" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><span style="font-synthesis: style; font-weight: 600;">好在导师的精神一直激励着大家</span>。从仪器设备的购买到安装再到开展实验,整个过程不到一个月,当PCR和稻瘟病菌实现转化那一刻,师生无不欢呼!</p>
<p data-pid="jne9H7Gr" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">因为暂时没有分配到温室,<span style="font-synthesis: style; font-weight: 600;">刚回国的李国田带领同学们还在狮子山北边开垦过荒地、建设过简易温室大棚。</span></p>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<figure data-size="normal" style="margin: 1.4em 0px;"><img src="https://pic3.zhimg.com/80/v2-81ee0069c57d4d54d7d296fd287315b6_720w.webp" data-caption="" data-size="normal" data-rawwidth="400" data-rawheight="301" class="content_image lazy" width="400" data-actualsrc="https://pic3.zhimg.com/v2-81ee0069c57d4d54d7d296fd287315b6_b.jpg" data-original-token="v2-81ee0069c57d4d54d7d296fd287315b6" height="301" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
</p>
<p data-pid="gpS6wqDu" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">还记得那是2020年2月,杨磊同学成了团队唯一一名留校的同学。因为肩负重任,他曾鼓足勇气,径直来到空无一人的山北试验田,纵然推开大棚那一刻有剧烈的不适应,但他终究打开了试验田的那扇大门。</p>
<p data-pid="xSrgwC8A" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">事后他自豪地说:<span style="font-synthesis: style; font-weight: 600;">“我照看并保护了水稻材料!我们当时成了全国继续科学研究的少数单位之一!”</span></p>
<p data-pid="cM75WIgY" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><span style="font-synthesis: style; font-weight: 600;">有了杨磊同学照看并收获的少数几粒种子,实验得以进一步开展。没有亲身经历“苦”,就不能真切感受“甜”。</span></p>
<p data-pid="UaCD2hHu" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">2023年6月14日深夜,李国田和团队的师生坐等成果上线,这一刻是苦尽甘来的最好时光……</p>
<p data-pid="TmSYOL7w" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">他们揭示了水稻广谱抗病机制的分子基础,为进一步探索作物抗病信号转导途径提供了新的线索和方法。从应用上讲,他们创造了一种新型的广谱抗病基因,为培育高产高抗的水稻品种提供了新的材料和技术。<span style="font-synthesis: style; font-weight: 600;">该团队表示,他们将继续深入开展相关研究,并与农业部门合作,推动该技术在实际生产中的应用,为保障国家粮食安全和农民收入做出贡献。</span></p>
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<figure data-size="normal" style="margin: 1.4em 0px;"><img src="https://pic1.zhimg.com/80/v2-ebb781d2d74faa61ebf63ece7845a300_720w.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="608" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic1.zhimg.com/v2-ebb781d2d74faa61ebf63ece7845a300_r.jpg" data-actualsrc="https://pic1.zhimg.com/v2-ebb781d2d74faa61ebf63ece7845a300_b.jpg" data-original-token="v2-ebb781d2d74faa61ebf63ece7845a300" height="608" data-lazy-status="ok" style="display: block; margin: 0px auto; height: auto; cursor: zoom-in; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044; width: 690px;"></figure>
<p class="ztext-empty-paragraph" style="margin-top: -0.8em; margin-bottom: -0.8em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><br>
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<p data-pid="YHbvd_eF" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">华中农业大学李国田教授团队在攻克“水稻癌症”方面取得了重大突破,他们用“分子剪刀”创造了一种新型的广谱抗病基因,并在Nature杂志上发表了一项具有里程碑意义的研究成果。他们展示了中国科学家在生物技术领域的创新能力和国际影响力,也为我国粮食安全和农业发展提供了有力支撑。</p>
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<p data-pid="4Tyq6eRG" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);"><span style="font-synthesis: style; font-weight: 600; font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif;"></span><span style="font-synthesis: style; font-weight: 600; font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif;"></span></p>
<p data-pid="oXkcazK7" style="margin-top: 1.4em; margin-bottom: 1.4em; color: rgb(18, 18, 18); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Microsoft YaHei", "Source Han Sans SC", "Noto Sans CJK SC", "WenQuanYi Micro Hei", sans-serif; font-size: medium; background-color: rgb(255, 255, 255);">内容来源:华中农业大学官网,<a href="https://uconf.com/" class=" wrap external" target="_blank" rel="nofollow noreferrer" data-za-detail-view-id="1043" style="color: inherit; text-decoration-line: none; border-bottom: 1px solid rgb(128, 128, 128); cursor: pointer;">爱科会易</a>仅用于学术交流</p>
